Evaluating Oxidative Stress Parameters, Pepsinogen, and Insulin-like Growth Factor-1 in Dairy Cows with Displacement of Abomasum
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Abstract
Introduction: Displacement of the abomasum (DA) frequently occurs in high-producing dairy cows. It is a multifactorial disease and has an economic impact on dairy farms. This study aimed to investigate the levels of pepsinogen, Insulin-Like Growth Factor-1, and oxidative stress parameters (malondialdehyde and nitric oxide) in DA cases.
Materials and methods: Blood samples were taken from 51 dairy cows suspected of DA, referring to the Veterinary Clinic of Shiraz University, Shiraz, Iran, in the summer of 2021. Twenty of them had Left DA (LDA), 6 had Right DA (RDA), 13 had LDA with clinical signs of ulcer of the abomasum, 3 had RDA with clinical signs of ulcer of the abomasum, and 9 of them (3-5 years old) were clinically healthy as control. The serum concentration of pepsinogen, Insulin-Like Growth Factor-1, malondialdehyde, and nitric oxide were measured.
Results: The result of the current study showed that the concentration of pepsinogen was higher in cows with DA compared to healthy cows. The concentrations of malonaldehyde, nitric oxide, and IGF-1 were higher in LDA with the abomasal ulcer, compared to other groups.
Conclusion: Pepsinogen can be suggested as a predictor parameter for DA. Malonaldehyde, nitric oxide, and IGF-1 can be considered biomarkers in LDA with the abomasal ulcer. However, further studies are needed to find other effective parameters for predicting DA.
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References
Guo YS, Tao JZ, Xu LH, Wei FH, and He SH. Identification of disordered metabolic networks in postpartum dairy cows with a left
displacement of the abomasum through integrated metabolomics and pathway analyses. J Vet Med Sci. 2020; 82(2):115-124. DOI:
https://doi.org/10.1292/jvms.19-0378
Doll K, Sickinger M, and Seeger T. New aspects in the pathogenesis of abomasal displacement. Vet J, 2009; 181(2): 90-96. DOI:
https://doi.org/10.1016/j.tvjl.2008.01.013
Song Y, Loor J, Zhao C, Huang D, Du X, Li X B, Wang Z, Liu G, and Li X. Potential hemo-biological identification markers to the left
displaced abomasum in dairy cows. BMC Vet Res. 2020; 16, 470. DOI: https://doi.org/10.1186/s12917-020-02676-x
Van Winden SC, and Kuiper R. Left displacement of the abomasum in dairy cattle: recent developments in epidemiological and etiological aspects. Vet Res. 2003; 34(1): 47-56. doi: 10.1051/vetres:2002060
Fiore F, Spissu N, Sechi S, and Cocco R. Evaluation of Oxidative Stress in Dairy Cows with Left Displacement of Abomasum. Animals (Basel). 2019; 9(11): 966. DOI: https://doi.org/10.3390/ani9110966
Piechotta M, Sander AK, Kastelic JP, Wilde R, Heppelmann M, Rudolphi B, Schuberth HJ, Bollwein H, and Kaske M. Short communication: Prepartum plasma insulin-like growth factor-I concentrations based on day of insemination are lower in cows developing postpartum diseases. J Dairy Sci. 2012; 95(3): 1367-1370. DOI: https://doi.org/ 10.3168/jds.2011-4622
Eckersall PD, and Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J. 2010; 185(1): 23-27. DOI: https://doi.org/ 10.1016/j.tvjl.2010.04.009
Souza DG, and Teixeira MM. The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue
injury and lethality during intestinal ischemia and reperfusion. Mem Inst Oswaldo Cruz. 2005; 100: 59-66. DOI: https://doi.org/
1590/S0074-02762005000900011
Grulke S, Franck T, Gangl M, Péters F, Salciccia A, Deby-Dupont G, and Serteyn D. Myeloperoxidase assay in plasma and peritoneal fluid of horses with gastrointestinal disease. Can J Vet Res. 2008; 72(1):37-42
Mesaric M, Zadnik T, and Klinkon M. Comparison of serum pepsinogen activity between enzootic bovine leukosis (EBL) positive beef cattle and cows with abomasal ulcers. Slov Vet Res. 2002; 39: 227-232. https://eurekamag.com/research/003/931/003931994.php
Samloff IM, Stemmermann GN, Heilbrun LK, and Nomura A. Elevated serum pepsinogen I and II levels differ as risk factors for duodenal ulcer and gastric ulcer. Gastroenterology. 1986; 90(3): 570-576. DOI: https://doi.org/ 10.1016/0016-5085(86)91110-8
Geishauser T. Abomasal Displacement in the Bovine-a Review on Character, Occurrence, Aetiology and Pathogenesis. J Vet Med
Ser A. 1995; 42: 229-251. DOI: https://doi.org/ 10.1111/j.1439-0442.1995.tb00375.x
Dorny P, and Vercruysse J. Evaluation of a micro method for the routine determination of serum pepsinogen in cattle. Res Vet Sci. 1998; 65(3): 259-262. DOI: https://doi.org/ 10.1016/S0034-5288(98)90153-9
Chagas LM, Bass JJ, Blache D, Burke CR, Kay JK, Lindsay DR, Lucy MC, Martin GB, Meier S, Rhodes FM, Roche JR, Thatcher WW, and Webb R. Invited review: New perspectives on the roles of nutrition and
metabolic priorities in the subfertility of high-producing dairy cows. J Dairy Sci. 2007; 90(9): 4022-32. DOI: https://doi.org/10.3168/jds.2006-852
Lean IJ, Van Saun R, and Degaris PJ. Energy and protein nutrition management of transition dairy cows. Vet Clin North Am Food Anim Pract. 2013; 29(2): 337-66. DOI: https://doi.org/10.1016/j.cvfa.2013.03.005
Roche JR, Kay JK, Friggens NC, Loor JJ, and Berry DP. Assessing and managing body condition score for the prevention of metabolic
disease in dairy cows. Vet Clin North Am Food Anim Pract. 2013; 29(2): 323-36. DOI: https://doi.org/ 10.1016/j.cvfa.2013.03.003
Williams, E. Drivers of Post-partum Uterine Disease in Dairy Cattle. Reprod Dom Anim. 2013; 48: 53-58. DOI: https://doi.org/
1111/rda.12205
Bernabucci U, Ronchi B, Lacetera N, and Nardone A. Influence of body condition score on relationships between metabolic status and
oxidative stress in periparturient dairy cows. J Dairy Sci. 2005; 88(6): 2017-2026. DOI: https://doi.org/10.3168/jds.S0022-0302(05)72878-2
Maden M, Ozturk AS, Bulbul A, Avci GE, and Yazar E. Acute-phase proteins, oxidative stress and enzyme activities of blood serum
and peritoneal fluid in cattle with abomasal displacement. J Vet Intern Med. 2012; 26(6):1470-1475. DOI: https://doi.org/
1111/j.1939-1676.2012.01018.x
Oliveira CP, Coelho AM, Barbeiro HV, Lima VM, Soriano F, Ribeiro C, Molan NA, Alves VA, Souza HP, Machado MC, and Carrilho FJ. Liver
mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease. Braz J Med Biol
Res. 2006; 39(2):189-94. DOI: https://doi.org/10.1590/s0100-879x2006000200004
Oliveira CP, da Costa Gayotto LC, Tatai C, Della Bina BI, Janiszewski M, Lima ES, Abdalla DS, Lopasso FP, Laurindo FR, and Laudanna AA.
Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet. J Cell Mol Med.
; 6(3):399-406. DOI: https://doi.org/ 10.1111/j.1582-4934.2002.tb00518.x.