_1737185940 20250118073900000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Farm Animal Health and Nutrition Farm Anim. Health Nutr. 2980-7905 12 07 2024 3 4 Sajjad Kazemi Ali Hajimohammadi https://orcid.org/0000-0001-7857-8636 Saeed Nazifi Introduction: The weaning process is a stressful phase for goat kids, impacting energy metabolism, antioxidant levels, and inflammatory responses, potentially hindering health and growth. Supplementing probiotics and yeast extracts may help mitigate these effects by improving gut health and immune responses. This study evaluated the relationship between oxidative stress markers and inflammatory parameters in Saanen goat kids during weaning. Materials and methods: The study involved 40 female Saanen goat kids with closely aligned birth dates (±2 days), randomly divided into four groups, Group 1 (n=10) received 1g/day probiotics (Pr), Group 2 (n=10) received 3g/day yeast cell wall extract (YC), Group 3 (n=10) received both supplements (1g Pr + 3g YC), and Group 4 (n=10) served as the control. Key parameters were cortisol, ferritin, nitric oxide (NO), total antioxidant capacity (TAC), triglycerides, and adenosine deaminase (ADA) and were measured to assess their associations and correlations during the weaning period under supplementation. Results: The results showed a significant negative correlation between ferritin and cortisol, as well as between nitric oxide (NO) and cortisol. While ADA was not directly associated with NO, a significant positive correlation was observed between them. TAC demonstrated significant negative correlations with both NO and triglycerides, with the latter showing a quadratic relationship. Conclusion: This study highlights the intricate interplay between stress parameters (cortisol, TAC, and NO), inflammatory markers (ferritin and ADA), and energy metabolism (triglycerides) during the weaning phase in goat kids. Supplementation with probiotics and yeast extract demonstrated potential benefits in modulating these physiological traits, reducing stress, and supporting overall health.        12 30 2024 78 83 https://creativecommons.org/licenses/by/4.0 10.58803/fahn.v3i4.64 https://fahn.rovedar.com/index.php/FAHN/article/view/64 https://fahn.rovedar.com/index.php/FAHN/article/download/64/89 https://fahn.rovedar.com/index.php/FAHN/article/download/64/89 10.3168/jdsc.2022-0300 10.1007/s11250-023-03695-0 10.1002/vms3.70142 10.3390/ani10040548 10.1016/j.tvjl.2024.106280 10.1007/s12257-020-0147-x Silva PS, Hooper HB, Manica E, Merighe GKF, Oliveira SA, Traldi AS, et al. Heat stress affects the expression of important placental genes, placental characteristics, and efficiency in Saanen goats, as well as the survival and growth of their offspring. J Dairy Sci. 2021; 104: 4970-4979. DOI: 10.3168/jds.2020-18301 Cheng Y, Yang C, Tan Z, and He Z. Changes of intestinal oxidative stress, inflammation, and gene expression in neonatal diarrhea kids. Front Vet Sci. 2021; 8: 598691. DOI: 10.3389/fvets.2021.598691 10.3389/fvets.2021.598691 10.3390/vetsci8060103 10.1186/s42523-021-00073-9 10.3168/jds.2020-18301 10.37496/rbz5120210216 10.1007/s11250-021-03034-1 10.1016/j.vetimm.2022.110517 10.3390/ani12040476 Nazifi S, Gheisari HR, and Shaker F. Serum lipids and lipoproteins and their correlations with thyroid hormones in clinically healthy goats. Veterinarski Arhiv. 2002:72(5), 249-257. 10.1007/s00580-022-03421-6 10.1016/j.tvjl.2007.07.006 10.1042/bj3570241 10.1016/j.livsci.2011.12.001 10.1016/j.smallrumres.2011.12.001 10.3168/jds.2014-8414 10.3390/nu9050521 10.1016/0028-3908(94)90100-7 10.1051/rnd:2004051 10.3923/pjn.2007.149.154 10.3923/ajbmb.2011.158.167 10.1515/pjvs-2016-0114