eng Rovedar Farm Animal Health and Nutrition 2980-7905 2024-12-30 3 4 78 83 10.58803/fahn.v3i4.64 66 Sajjad Kazemi 0 Ali Hajimohammadi 1 https://orcid.org/0000-0001-7857-8636 Saeed Nazifi 2 Resident of Large Animal Internal Medicine, Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Associate Professor of Large Animal Internal Medicine, Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Professor of Clinical Pathology, Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Introduction: The weaning process is a stressful phase for goat kids, impacting energy metabolism, antioxidant levels, and inflammatory responses, potentially hindering health and growth. Supplementing probiotics and yeast extracts may help mitigate these effects by improving gut health and immune responses. This study evaluated the relationship between oxidative stress markers and inflammatory parameters in Saanen goat kids during weaning. Materials and methods: The study involved 40 female Saanen goat kids with closely aligned birth dates (±2 days), randomly divided into four groups, Group 1 (n=10) received 1g/day probiotics (Pr), Group 2 (n=10) received 3g/day yeast cell wall extract (YC), Group 3 (n=10) received both supplements (1g Pr + 3g YC), and Group 4 (n=10) served as the control. Key parameters were cortisol, ferritin, nitric oxide (NO), total antioxidant capacity (TAC), triglycerides, and adenosine deaminase (ADA) and were measured to assess their associations and correlations during the weaning period under supplementation. Results: The results showed a significant negative correlation between ferritin and cortisol, as well as between nitric oxide (NO) and cortisol. While ADA was not directly associated with NO, a significant positive correlation was observed between them. TAC demonstrated significant negative correlations with both NO and triglycerides, with the latter showing a quadratic relationship. Conclusion: This study highlights the intricate interplay between stress parameters (cortisol, TAC, and NO), inflammatory markers (ferritin and ADA), and energy metabolism (triglycerides) during the weaning phase in goat kids. Supplementation with probiotics and yeast extract demonstrated potential benefits in modulating these physiological traits, reducing stress, and supporting overall health.        https://fahn.rovedar.com/index.php/FAHN/article/view/64 Inflammatory response Probiotic Saanen goat Yeast extract