Evaluating Oxidative Stress Parameters, Pepsinogen, and Insulin-like Growth Factor-1 in Dairy Cows with Displacement of Abomasum

Document Type : Original Article


Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran


Introduction: Displacement of the abomasum (DA) frequently occurs in high-producing dairy cows. It is a multifactorial disease and has an economic impact on dairy farms. This study aimed to investigate the levels of pepsinogen, Insulin-Like Growth Factor-1, and oxidative stress parameters (malondialdehyde and nitric oxide) in DA cases.
Materials and methods: Blood samples were taken from 51 dairy cows suspected of DA, referring to the Veterinary Clinic of Shiraz University, Shiraz, Iran, in the summer of 2021. Twenty of them had Left DA (LDA), 6 had Right DA (RDA), 13 had LDA with clinical signs of ulcer of the abomasum, 3 had RDA with clinical signs of ulcer of the abomasum, and 9 of them (3-5 years old) were clinically healthy as control. The serum concentration of pepsinogen, Insulin-Like Growth Factor-1, malondialdehyde, and nitric oxide were measured.
Results: The result of the current study showed that the concentration of pepsinogen was higher in cows with DA compared to healthy cows. The concentrations of malonaldehyde, nitric oxide, and IGF-1 were higher in LDA with the abomasal ulcer, compared to other groups.  
Conclusion: Pepsinogen can be suggested as a predictor parameter for DA. Malonaldehyde, nitric oxide, and IGF-1 can be considered biomarkers in LDA with the abomasal ulcer. However, further studies are needed to find other effective parameters for predicting DA.